NLM Journal Club - Next/Latest Meeting

Date, Paper, and Presenter:

October 29, 2023 Review of previously covered nominated papers [Xiong et al. 2015] [Holler et al. 2021] [Goto et al. 2021] [Choi et al. 2018] [Choi et al. 2021] Presenter: Kenneth Hayworth

Announcement:

For our next journal club (this Sunday, October 29 at 4pm EDT, at https://carboncopies.org/aspirational-neuroscience) I will lead an open chat about a set of papers that we have covered in previous journal clubs that I personally think are strong contenders for this year’s Aspirational Neuroscience awards. Here is the list of papers I plan to discuss, but THE FLOOR WILL BE OPEN to discuss any other research we should be considering:


1.) Xiong et al. 2015 “Selective corticostriatal plasticity during acquisition of an auditory discrimination task”
     Paper link: https://www.nature.com/articles/nature14225
     JC video link: https://www.youtube.com/watch?v=5sm8vEsE7gg

2.) Holler et al. 2021 “Structure and function of a neocortical synapse”
     Paper link: https://www.nature.com/articles/s41586-020-03134-2
     JC video link: https://www.youtube.com/watch?v=eQooB_Q5Eio

3.) Goto et al. 2021 “Stepwise synaptic plasticity events drive the early phase of memory consolidation”
     Paper link: https://www.science.org/doi/full/10.1126/science.abj9195
     JC video link: https://www.youtube.com/watch?v=saFDeGTYnRU

4.) Choi et al. 2018 “Interregional synaptic maps among engram cells underlie memory formation” and Choi et al. 2021 “Synaptic correlates of associative fear memory in the lateral amygdala”
     Paper link: https://www.science.org/doi/full/10.1126/science.aas9204
     Paper link: https://www.sciencedirect.com/science/article/pii/S089662732100502X
     JC video link: https://www.youtube.com/watch?v=PWiT7Q4UG7g

Please join us to discuss. 

Journal Club

Our Neuroscience of Learning and Memory (NLM) Journal Club meets roughly fortnightly (Meet or Zoom), depending on schedules. Meeting Invites are sent out by Google Calendar. We also have an NLM Google Group (listserv). Membership in both is reserved for neuroscience students and postdocs, and practicing neuroscience researchers. 

Our JC and listserv are free and educational in purpose. We seek to help each other understand knowns and unknowns in the neuroscience of learning and memory by evaluating both classic and recent papers, models, experiments, literature and open questions in the field. Neuroscientific work involves processes of description, classification, modeling, control, prediction, and understanding. We are interested in all of these. Our NLM JC is particularly focused on the “big question” of what kind of high-level information  can eventually be retrieved from high-resolution static connectome imagery and structure-function relationships, and represented in computer emulations. The goal of decoding non-trivial memory, in any animal model, is admittedly aspirational today, but it seems increasingly plausible given our current models, tools and advances.

Given this question, our JC is especially interested in the physical and informational bases of perception, encoding, storage, and recall of hippocampal and long-term memories, in high-resolution connectomics, in neural imaging and recording, in engram manipulation tools and techniques, and in computational neuroscience and neuro-inspired AI. We also use the JC and listserv to share a low volume of NLM-related news, research, recent advances, and review papers. All members are welcome to nominate papers for discussion, including self-nominations. Both the JC and listserv are forums for respectful discussion and debate, sharing unfettered opinions and insights, and making new friendships.

To encourage frank discussion, we use Chatham House rules—each member is free to use what is discussed in group, but sources remain confidential, unless permission is granted by the source.

Our JC typically meets Sunday Afternoon (3pm Eastern) on Google Meet or Zoom. All members are welcomed to present or lead discussions. Attendance is entirely optional, and many of our members post and attend JCs only occasionally.

Meeting Formats include:

  1. Single Paper Presentations and Discussions (in-depth on a particular paper, typically more formal)
  2. Dual Paper Presentations and Discussions (comparing two models or techniques, less formal)
  3. Single Topic Exploratory Meetings (a specific educational goal or research question, less formal)
  4. Multi Topic Exploratory Meetings (multiple topics, discussions led by multiple JC members, informal)
  5. AMA Meetings (investigators are invited to answer questions from JC members, informal)
  6. Book Club Meetings (introduction and discussion of new technical and trade books, informal)

 

Meeting Notes (when there are volunteers to take and post them) are posted afterward to the listserv. The listserv is also a great place to give updates to colleagues, ask questions, share draft papers, post relevant papers and news, and engage in friendly discussion of memory encoding, retrieval, manipulation, preservation, scanning, and emulation and other NLM-related topics.

Podcasts are great onramps to community practice in many subjects. Some podcasts we recommend in relation to our JC are listed below, in alpha order. Let us know your favorites, for neuroscience audiences.

  • Brain Inspired. Host Paul Middlebrooks delves deep into neuroscience, computational neuroscience, artificial intelligence, and the intersections between them. Good coverage of the neuroscience of learning and memory.
  • Brain Matters. Hosted by fledgling neuroscientist Anthony Lacagnina, at UT Austin. Wide ranging discussions with neuroscientists, often covering topics related to learning and memory.
  • Data Skeptic. Hosted by Kyle Polich, this podcast takes a skeptical look at data science, machine learning, and statistics, often featuring interviews with experts. Topics sometimes include neuroscience and its relationship to AI.
  • Neuromatch Academy. A nonprofit working to democratize access to neuroscience education and jobs. Their podcasts, in conjunction with Brain Inspired, discuss computational neuroscience and interview experts in the field.
  • New Books in Neuroscience. Produced by the New Books Network. Interviews with neuroscientists (30-60 mins) about their recently published books. Both broad and technical coverage, occasional learning and memory topics.
  • Talking Machines. Hosted by Katherine Gorman and Neil Lawrence. Primarily focuses on machine learning, but often interviews experts who discuss the neural basis of learning and decision making.
  • The Brain Science Podcast. Hosted by Ginger Campbell, this podcast covers a wide variety of neuroscience topics, including some computational neuroscience and memory topics.
  • The Language Neuroscience Podcast. Neuroscientist Stephen Wilson talks with leading neuroscientists working on the scientific study of language. For a neuroscience audience.

Who Can Join?

Graduate students, postdocs, academics, medical and industry practitioners and researchers in neuroscience, biophysics, psychology, cognitive science,  engineering, mathematics, and computer science. Graduate students, academics and practitioners in other fields are also welcome to apply to join. Undergraduates and others may apply, if they are or have previously engaged in NLM-related research or applications.

Apply to Join (Form)

Previous Journal Clubs

October 29, 2023 Review of previously covered nominated papers [Xiong et al. 2015] [Holler et al. 2021] [Goto et al. 2021] [Choi et al. 2018] [Choi et al. 2021] Presenter: Kenneth Hayworth

October 15, 2023 Song et al. 2023 “High-contrast en bloc staining of mouse whole-brain and human brain samples for EM-based connectomics” and Lu et al. 2023 “A Scalable Staining Strategy for Whole-Brain Connectomics” Presenter: Kenneth Hayworth

October 1, 2023  Hayashi-Takagi et al. 2015 “Labelling and optical erasure of synaptic memory traces in the motor cortex” Presenter: Kenneth Hayworth 

September 3, 2023  Choi et al. 2021 “Synaptic correlates of associative fear memory in the lateral amygdala” Presenter: Kenneth Hayworth

August 20, 2023       Khona & Fiete 2022  “Attractor and integrator networks in the brain”  Presenter: Kenneth Hayworth   

August 6, 2023         Kim et al. 2023 “Mapping memories: pulse-chase labeling reveals AMPA receptor dynamics during memory formation” Presenter: Kenneth Hayworth

July 23, 2023             Shiu et al. 2023 “A leaky integrate-and-fire computational model based on the connectome of the entire adult Drosophila brain reveals insights into sensorimotor processing” Presenter: Oge Nnadi

May 7, 2023               Markram et al. 2015 “Reconstruction and simulation of neocortical microcircuitry”      Presenter: Kenneth Hayworth

December 21, 2022  Bahramisharif et al. 2018 “Serial representation of items during working memory maintenance at letter-selective cortical sites”   Presenter: Randal Koene  [VIDEO]

December 4, 2022  Goto et al. 2021 “Stepwise synaptic plasticity events drive the early phase of memory consolidation”  Presenter: Kenneth Hayworth  [VIDEO]

November 27, 2022 Billeh et al. 2020 “Systematic Integration of Structural and Functional Data into Multi-scale Models of Mouse Primary Visual Cortex”  Presenter: Charl Linssen   [VIDEO]

November 13, 2022  Park et al. 2019 “Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons”  Presenter: Kenneth Hayworth  [VIDEO]

September 25, 2022 Holler et al. 2021 “Structure and function of a neocortical synapse”  Presenter: Kenneth Hayworth  [VIDEO]

September 15, 2022  Xiong et al. 2015 “Selective corticostriatal plasticity during acquisition of an auditory discrimination task”  Presenter: Kenneth Hayworth [VIDEO]

Older BPF Journal Clubs with videos:

December 12, 2020 Rossi et al. 2020 “Spatial connectivity matches direction selectivity in visual cortex”  Presenter: Kenneth Hayworth [VIDEO]

March 30, 2019        El-Boustani et al. 2018 “Locally coordinated synaptic plasticity of visual cortex neurons in vivo” Presenter: Kenneth Hayworth  [VIDEO]

September 5, 2018    Choi et al. 2018 “Interregional synaptic maps among engram cells underlie memory formation” Presenter: Kenneth Hayworth  [VIDEO]

July 25, 2018              Kasai et al. 2003 “Structure–stability–function relationships of dendritic spines” Presenter: Kenneth Hayworth  [VIDEO]

July 23, 2018              Abdou et al. 2018 “Synapse-specific representation of the identity of overlapping memory engrams” Presenter: Kenneth Hayworth [VIDEO]