Abdou, K., Shehata, M., Choko, K., Nishizono, H., Matsuo, M., Muramatsu, S. I., &
Inokuchi, K. (2018). Synapse-specific representation of the identity of overlapping memory
engrams. Science, 360(6394), 1227-1231.
https://science.sciencemag.org/content/360/6394/1227.abstract
c-Fos::tTA transgenic mice and optogenetics
Amygdala
Is an auditory fear memory stored in LA engram cells or LA synapses? Using clever
genetic tools Abdou et al. shows that the memory is stored in the synapses.
“This study uncovered the mechanism by which the brain can maintain the uniqueness
of a massive number of associated memories stored in shared cell ensembles. Furthermore, we
achieved selective and total erasure of a fear memory from an engram network without affecting
other memories stored in the shared ensemble by resetting the plasticity in a synapse specific
manner.”
BPF Journal Club
