Reference:
Penn, A. C., Zhang, C. L., Georges, F., Royer, L., Breillat, C., Hosy, E., … & Choquet, D.
(2017). Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature,
549(7672), 384. https://www.nature.com/articles/nature23658.pdf
Technique:
Electrophysiology, receptor tagging
System:
Hippocampus slice
Summary:
Demonstrates that AMPA receptor surface diffusion is crucial to synaptic
potentiation.
Quote:
“Our results provide a direct demonstration that the recruitment of new receptors to
synapses by surface diffusion is a critical mechanism for the expression of LTP and
hippocampal learning.”